The awesome thing about video games is that anything is easily possible. Lost an arm or leg? No biggie, regardless of whether you're good or bad, it's gonna get replaced with a mechanical part, the chances are higher of course, in a sci-fi world. Of course, there are other characters who voluntarily replace their flesh and bones with something more durable to release themselves from their organic shackles.
It's the logical choice especially in many settings and for some characters to keep up with unfair superpowered villains or heroes. Narrative-wise, cyborgs are also some of the most interesting characters because these guys have gone through loss and that makes them more relatable and dramatic. The result is that cyborgs in video games are always memorable; these half-robots prove that much.
10 Johnny Silverhand (Cyberpunk 2077)
One of the recent additions here, Johnny Silverhand just woke the eff up and started telling players what to do while being one of the nastiest rebels in Cyberpunk 2077. Voiced by none other than Keanu Reeves, Johnny gets associated with the player's character by chance.
Since then, he's been plaguing their heads and giving some polarizing advice on Night City's state of affairs. The catch is that Johnny is actually dead and only lives as an uploaded program so he probably can't hurt you no matter how many robot dogs you shoot.
9 Prophet (Crysis)
Much like the video game, Crysis, the nanosuits in the game world are also way too demanding for the regular Joe. Turns out they're a living and breathing armor made out of alien components and they tend to fuse themselves to their wearers.
If removed, then there's a huge chance that their wearer will die after being dependent on them. That effectively makes Prophet, one of the main faces of Crysis, as well as the rest of the boys, cyborgs. With how they move and fight, that should be pretty explanatory.
8 Venom Snake (Metal Gear Solid)
It might have a pseudoscientific and military fetish, but there's no denying that the lore in Metal Gear is nevertheless interesting. Even as early as the 1980s, the series has been churning out cyborgs and low-tech cybernetics in the form of Venom Snake's prosthetic hand.
It's subtle but pretty much functions like a regular hand. More than that, it packs quite a punch— literally, as it can be used to incapacitate hapless Soviet soldiers stuck under the Afghan sun. Honorable mentions go to Revolver Ocelot and future iterations of Snake who might have ingested too many nanomachine plot devices.
7 Raiden (Metal Gear Rising: Revengeance)
Speaking of nanomachines, here's Metal Gear Rising: Revengeance. Raiden likely represents the peak of Metal Gear cybernetics along with the invincible Senator Armstrong who's too jacked up in nanomachines to care about fairness.
It's nothing too hard for Raiden, however. Apart from cybernetically augmented strength, speed, and angst, Raiden also has a penchant for having some convenient blades tucked into his joints and if the going gets tough, he can also vanish from thin air with a top-of-the-line cloaking tech.
6 Adam Jensen (Deus Ex)
If Raiden is too much for you, then maybe a more reasonably sensible cyborg like Adam Jensen is more believable. Adam loves to abide by the rules of his own world and usually doesn't act or perform combat like a superhero.
His cybernetics are a result of his being a perfect candidate as well as an attempt to preserve his life after a debilitating combat injury. As far as augmentations go, Adam is a Swiss Army knife and is enhanced in multiple aspects from hacking and athleticism to even social skills.
5 Master Chief (Halo)
You would have had to live under a rock for the past 2 decades in order to not know or at least recognize Master Chief from the Halo franchise. One of the most ubiquitous poster boys of gaming is actually a cyborg underneath that swaggy suit.
That's because in order to use his special Spartan armor, Master Chief had to undergo several cybernetic augmentations. His upgrades are not as boastful or apparent as other cyborgs,' usually just a Spartan Neural Interface but these grant him superhuman-levels of physical capabilities.
4 Commander Shepard (Mass Effect)
Much like Master Chief, Commander Shepard is an icon and when not being a space swinger during his rest days, he's usually ripping apart troublemakers in the Milky Way. In the first game, he's more or less organic, but come the second title, Shepard got an overhaul.
He practically died and was brought back to life by Cerberus using advanced technology and cyber improvements. By that time and until the third game, he's no longer just a regular human and has become some sort of cyborg Frankenstein.
3 Big Daddy (Bioshock)
For retro-futuristic "cyborgification," look no further than Bioshock's resident roaming enforcers, the Big Daddy. These hulking masses are humans who got spliced so much that they became something else and were fused with a menacing diving suit and typically a drill for one of its arms.
As far as unconventional video game cyborgs go, the Big Daddy is the most unique. The fact that it exists in a steampunk or dieselpunk world is interesting enough. Even the sequel is based around them.
2 Barret Wallace (Final Fantasy)
Barret Wallace is one of the oldest cyborgs around, dating back from 1997 in Final Fantasy VII where he was introduced as a tall and fearsome comrade of the good guys. His cyborg qualities are more subtle though and are only apparent in his gun-arm.
Instead of making it a functional fake hand like most normal cyborgs who lost their arm, Barret thought that he probably could use a gun more despite being in a world where anything is possible. We don't judge him for his choice, though he really needed a hand.
1 Cyberdemon (Doom)
Now for a change of scenery, here's a bad guy instead, courtesy of the Doom franchise. The Cyberdemon has always been one of the most disturbing meanies in those games and he represents other evil cyborg anomalies in the game as well.
He mostly appeared as a mini-boss and tougher-than-usual demon in the earlier games but Doom 2016 officially made Cyberdemon into a boss. And guess what? He's angry at the players for thinking that only humans are allowed to be cyborgs, so he's always trying his best to kill you, for the sake of demon-kind inclusivity.