Statistically speaking, most people do not much care for insects. It's understandable; while insects of all kinds are essential to our ecosystem, they're also creepy, intrusive, and occasionally very painful. Some video game characters have taken special note of that last point, realizing that getting insects under your direct control gives you a nearly-endless source of perpetually angry living weapons.
Truly, to become a master of the insect world is to become a one-man army, and when people see you slinging creepy crawlies at them, they know their only choices are to run the heck away or end up like Nicolas Cage in The Wicker Man.
10 Jack - BioShock
BioShock's Plasmids are a result of ADAM-induced gene editing, allowing a normal human to manifest superhuman abilities. Most of these abilities have practical applications, like lighting the stove with Incinerate or lifting a sofa with Telekinesis. The Insect Swarm Plasmid, however, is a bit of a head-scratcher, as it creates a hive of live bees within the user's hand. Why anyone would want a fistful of bees, outside of shooting them at people, is unknown, but if nothing else, Jack put the ability to good use throughout his lovely little visit to the city of Rapture.
9 Arakune - Blazblue Series
Arakune's brief dip into the Boundary transformed his body into a pulsating mass of raw magical elements. That amorphous form allows him to contort his body in a variety of... interesting ways, but in addition to that, his body also conceals a theoretically infinite swarm of dangerous poison insects. Arakune can launch these insects like projectiles, or by using his Drive Ability, curse his foes, drawing the insects out toward them. Curses are another kind of magic, after all, and there are few curses as old-school as swarms of violent insects.
8 The Pain - Metal Gear Solid 3: Snake Eater
The Pain's entire body is like a giant beehive, with multiple species of aggressive hornets just kind of hanging out in there. The Pain has full command over this swarm, able to launch them at foes and, somehow, have them summon a small Tommy gun for him.
The original explanation for these abilities was that The Pain was stung so much by hornets, they just kind of got used to him, though this was retconned in Metal Gear Solid 5 to him using special hormone-secreting parasites. Still doesn't explain where that gun came from, though.
7 Hornet Man - Mega Man 9
Dr. Light originally built Hornet Man to manage local gardens and bee populations, giving him extensive knowledge on the subjects of beekeeping and pollination. When he was tricked and reprogrammed by Dr. Wily, that knowledge of bees was turned to destructive purposes.
Hornet Man's signature weapon is the Hornet Chaser, which launches large robotic (and admittedly kind of cute) bees at foes. Technically, since the bees are robots, you might not count them as true insects, but Hornet Man likes real bees enough that we can probably give him a pass on that one.
6 The Gungeoneers - Enter The Gungeon
When you're traversing the depths of the Gungeon, you can't afford to be picky about your weaponry. If it fits in one hand and launches some manner of a projectile, you can call it a gun, no exceptions. Case in point, there are several weapons utilized by the Gungeoneers that are insect-based, including the fire-spewing Gungeon Ant, the Stinger - a missile launcher that explodes into swarms of bees, and the Beehive, which is... well, a beehive, utilized by vigorously shaking it. As we said, you can't be picky.
5 The Stranger - Oddworld: Stranger's Wrath
As a well-trained outdoorsman, the Stranger is naturally in tune with the ways of nature, including its fauna. This, along with his general distaste for firearms, led him to utilize the world's various insect and small animal species as ammunition for his crossbow, which actually makes it much more effective than a traditional pistol. Some standouts of Stranger's insectoid arsenal include the electrically-charged Zappfly, the rapid-firing Stingbee, and the long-shooting Sniper Wasp. As for why the insects don't just fly away when the Stranger loads them, more than likely they either like him or fear him.
4 The AntAgonizer - Fallout 3
The AntAgonizer is the queen of ants, terrorizing the small town of Canterbury Commons with her legion of gigantic mutant worker ants. She was an orphaned girl who was raised by ants to despise humanity and seeks to conquer the world in their name. Or at least that's the backstory she lifted off an issue of Grognak the Barbarian. In actuality, Tanya Christoff experienced severe emotional trauma as a child when her parents were killed by giant ants, leading her to co-opt the AntAgonizer persona as a means of coping with her grief.
3 Agitha - Hyrule Warriors
In her original appearance in The Legend of Zelda: Twilight Princess, Agitha, the self-proclaimed "Princess of the Insect Kingdom," isn't a combatant. She merely asks link to gather insects for her so they can host a party together. In Hyrule Warriors, however, unusual times conspire to place her on the battlefield, where it turns out her title may be for real. Agitha can conjure forth a variety of butterflies and beetles to flit about the field, overwhelming monsters with their remarkable strength and size. Perhaps it's a good thing Link did her bidding before.
2 D'vorah - Mortal Kombat Series
D'vorah is a Kytinn, a species of Outworld, who are basically insects in humanoid form. It's not so much that D'vora commands the insects in her body as they simply are her. The bugs are an extension of her flesh and her will, and follow her every command like a drone serving a queen. Using this internal swarm, she can blow clouds of flies into an opponent's face, toss explosive grubs at them, and if the situation demands it, shed her humanoid form and become a gigantic insect brood mother.
1 Marguerite Baker - Resident Evil 7
Eveline's mold causes a variety of dangerous and unusual effects in those it infects. Marguerite Baker, for instance, received not just the usual enhanced strength and regenerative abilities, but the ability to control swarms of vicious insects and arachnids. These critters all hatched from eggs produced by the mold, and they share a hive mind with Marguerite herself, allowing her not only to control where they spawn nearby but also house them within her own body. Marguerite and her insects were so closely linked, that when she was killed by Ethan Winters, they all died immediately.