Just as you can craft your own equipment and cook your own meals, you can also mix up your own medicine in Rune Factory 4. In fact, with the Chemistry Set you can be so self-reliant that you even make up special fertilizers for all of your farming needs.
It won't be far into the game that you start making your own supplies and improving your chemistry skill. Not only will this help you survive on your perilous journeys outside Selphia, but it can even be quite the handy money-making strategy!
Updated on June 14, 2023: We've updated this guide covering chemistry basics and all the chemistry recipes so you can be a medicine master in Rune Factory 4!
Chemistry Basics
Once you have acquired the appropriate license via an order, you can purchase Chemistry Labs from either Jones or Nancy when they are working at the clinic. This will cost you some gold, some lumber, and some material stone.
Once you have the Chemistry Set installed, you can start making restorative items, farming items, cooking ingredients, and eventually even stat boosters.
When using the Chemistry Set, you will use Rune Points (RP) whenever you attempt a recipe.
If the item's level is higher than your chemistry level, it will cost more RP to attempt to make it and there is a chance the attempt could outright fail — this will leave you with an Object X, a mysterious item that can be surprisingly useful.
You can learn recipes in-game by consuming Medicine Bread bought from Porcoline or acquired from festivals.
Alternatively, you could follow the recipes listed in this guide by selecting the "Do not use recipe" option, though it costs considerably more RP the first time you make something this way.
All Chemistry Recipes
When an ingredient is listed in italics, that means you can use any item of that ingredient's category.
Restorative Items
|
Item |
Level |
Recipe |
|---|---|---|
|
Recovery Potion |
3 |
Medicinal Herb, Green Grass |
|
Roundoff |
13 |
Black Grass, Black Grass |
|
Recovery Potion |
15 |
Blue Grass |
|
Para-Gone |
18 |
Indigo Grass, Indigo Grass |
|
Healing Potion |
20 |
Medicinal Herb, Red Grass |
|
Cold Medicine |
22 |
Orange Grass, Toyherb |
|
Antidote Potion |
25 |
Antidote Grass, Toyherb |
|
Roundoff |
28 |
Moondrop |
|
Para-Gone |
31 |
Pink Cat |
|
Cold Medicine |
32 |
Charm Blue |
|
Mystery Potion |
33 |
Medicinal Herb, White Grass |
|
Antidote Potion |
38 |
Cherry Grass |
|
Healing Potion |
40 |
Pom-Pom Grass |
|
Magical Potion |
45 |
Medicinal Herb, Elli Leaves |
|
Formuade |
46 |
Heavy Spice, Lamp Grass, Ironleaf, Powders and Spores, Liquids |
|
Mystery Potion |
60 |
Autumn Grass |
|
Formuade |
65 |
Hot-Hot Fruit |
|
Magical Potion |
70 |
Fireflower |
|
Invinciroid |
76 |
Noel Grass, Emery Flower, Autumn Grass, Hot-Hot Fruit, Formuade |
|
Invinciroid |
86 |
Giant Hot-Hot Fruit, Formuade |
|
Love Potion |
87 |
Emery Flower, Pink Melon, Strawberry, Honey, Hot-Hot Fruit, Grape Liqueur |
|
Love Potion |
97 |
Great Emery Flower |
Cooking Items
|
Item |
Level |
Ingredients |
|---|---|---|
|
Sweet Powder |
5 |
Apple |
|
Sour Drop |
7 |
Orange |
|
Mixed Herbs |
8 |
Green Grass, Toyherb |
|
Heavy Spice |
10 |
Purple Grass |
Farming Items
|
Item |
Level |
Recipe |
|---|---|---|
|
No Rot α |
26 |
Withered Grass, Toyherb |
|
Formula A |
29 |
Withered Grass, Blue Grass, Black Grass |
|
Wettable Powder |
30 |
Charm Blue, Cherry Grass |
|
Greenifier |
34 |
Withered Grass, Indigo Grass, Moondrop Flower |
|
Formula B |
41 |
Yellow Grass, Pink Cat, 4-Leaf Clover |
|
No Rot ß |
50 |
Withered Grass, Red Grass, 4-Leaf Clover |
|
Minimizer |
53 |
Ironleaf |
|
Giantizer |
57 |
Lamp Grass |
|
Greenifier+ |
64 |
Withered Grass, Orange Grass, Corn |
|
Formula C |
72 |
White Grass, Fireflower, Corn |
Stat Boosters
|
Item |
Level |
Recipe |
|---|---|---|
|
The Protein |
80 |
Red Crystal, Red Crystal, Spinach, Powders and Spores, Liquids |
|
Intelligencer |
82 |
White Crystal, White Crystal, Eggplant, Powders and Spores, Liquids |
|
Vital Gummi |
83 |
Blue Crystal, Blue Crystal, Bok Choy, Powders and Spores, Liquids |
|
Heart Drink |
85 |
Green Crystal, Green Crystal, Ironleaf, Powders and Spores, Liquids |
|
The Protein |
90 |
Big Red Crystal |
|
Intelligencer |
92 |
Big White Crystal |
|
Vital Gummi |
93 |
Big Blue Crystal |
|
Heart Drink |
95 |
Big Green Crystal |
|
Leveliser |
96 |
Emery Flower, 4-Leaf Clover, Noel Grass, Autumn Grass, Fireflower, Hot-Hot Fruit |
|
Leveliser |
99 |
Great Emery Flower, Great 4-Leaf Clover |