Spider-Man: No Way Home screenwriters Chris McKenna and Erik Sommer have discussed Uncle Ben's involvement in the MCU following some of the film's reveals. Spoilers for No Way Home below.
During the final act of No Way Home, we finally get to see the famous "with great power comes great responsibility" line, but this time delivered by Aunt May instead of Uncle Ben. This led Marvel fans to wonder whether or not this universe even has an Uncle Ben, as all we've really seen of him are his initials on a suitcase in Far From Home.
No Way Home screenwriters Chris McKenna and Erik Sommer talked to The Hollywood Reporter about some of the twists and turns of No Way Home, including the scene with Aunt May. When asked about it, the two end up discussing how Uncle Ben factors into this Peter's life when compared to other versions of the character.
Sommers said, "This iteration of Spider-Man didn’t start by telling the story of losing Uncle Ben. We started at a different place with Peter. Those words are so tied to Uncle Ben, there didn’t seem to be a natural place for it. We weren’t even thinking necessarily, “Oh, we have to do it in this one.” As the story started to develop, and as we got to the scene with May, we realized, “This is going to be Peter’s Uncle Ben,” and the words are going to come out."
McKenna continued, "You just leap over it, but it leaves so many questions and gaps. Some people ask, “Oh, did Uncle Ben die? Was he guilty? Are we losing that gravitas as part of that character?” I think that’s something we’ve always discussed. “What is the deal with his Uncle Ben? Is it a total parity — is it one to one? Is it absolutely the same way?” We started thinking, “Well maybe it’s not. Maybe his mentor is May and she’s instilled this thing in him."
The main takeaway from the Sommers and McKenna is that "Hopefully you start seeing this is a different Peter Parker. They are all different. They have had different origins. They have had different contexts".