The 15 Most Powerful Enemies In Fallout 4

Fallout 4 was met with mediocre reception. Following the game changing Fallout 3 and subsequent cult hit Fallout: New Vegas, the bar was set pretty high for Fallout 4 and a lot of gamers would say that Bethesda missed. Although the game featured extremely refined shooting mechanics, an inspired wasteland to explore, and, even in this day and age, an amazing amount of interaction and interactivity with between the player and the game world, players and critics were generally unimpressed. The spark that seemed to make Fallout 3 such an engrossing experience didn't seem to be present in the latest iteration of the Fallout franchise and the games reputation suffers to this day.

Despite the lack of enthusiasm for Fallout 4, one thing cannot be denied: the enemy design in the game is magnificent. Super Mutants sporting armor made from pieces of debris and relicts of the world before the Great War. Deathclaws confidently stalking any foolhardy adventurer brainless enough to wander into their territory. Nightmarish mutated animals and insects that haunt the stagnant wilds of the wasteland. Say what you will, but the enemies in Fallout 4 are undoubtedly the best designed in the entire franchise. With that merit comes the fact that it also includes some of the most powerful and dangerous enemies to grace the nuclear-scarred wastes.  This list is just a few of the most gruesome, brutal, and downright deadly creatures that you'll encounter in your post-apocalyptic adventures. With that, pop open a Nuka-Cola and lets begin the countdown!

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15 Vampiric Bloodbug


One of the peskiest enemies in the game, Bloodbugs can be a real nuisance to any player traversing Fallout 4’s wasteland. Essentially giant mutated mosquitos, Bloodbugs gradually evolve over the game from buzzing bother to seriously deadly threat. No other variant of the Bloodbug is as powerful as the Vampiric Bloodbug, the highest tier of the species. They have extremely high tolerance for damage—for a Bloodbug at least—and are able to suck the player dry in a matter of seconds with their long, piercing proboscis.

In addition, Bloodbugs are rarely confronted alone; where there is one mutated giant mosquito, there are guaranteed to be more in toe. Due to their tendency to travel in groups and the fact that they are incredibly difficult to hit outside of VATS, Vampiric Bloodbugs are an enemy that require more than a simple flyswatter to defeat. Make sure you’re carrying a surplus of ammo if you plan to take on a swarm of Vampiric Bloodbugs; not because they’re especially tough but because they’re so damn hard to hit.

14 Gangrenous Feral Ghoul


Sharing the appearance of a normal Feral Ghoul, save for a sickly yellowish pallor, Gangrenous Feral Ghouls are standout as a threat in Fallout 4. Considerably rare in comparison to the other types of Feral Ghoul that roam the wasteland, Gangrenous Feral Ghouls are particularly a threat when encountered in a pack of lesser Ghouls. With comparably high hit points and fiercely powerful, lightening fast swipes, Gangrenous Feral Ghouls can dispose of a player with ease.

Although they can be easily disposed of, as with most types of Feral Ghouls, if Gangrenous Feral Ghouls are able to close the distance without being gunned down first, they can pose a serious threat to any player, especially when dealing with a horde of their less powerful kin. Players should be wary when approaching a room of slumbering Ghouls; if you spot one with yellowish skin, it may be best to try and eradicate the problem from a distance.

13 Annihilator Sentry Bot Mk. II


One of the wastelands deadly robot adversaries, The Annihilator Sentry Bot Mk.II is an enemy that is worth avoiding, if possible. A heavily armored, fast moving, humanoid battle platform, they are relentless in their deadly purpose if they acquire the player. They are heavily armored and able to deal an insane amount of damage thanks to their multiple weapons systems. The Annihilator Sentry Bot Mk.II is equipped with a flamethrower, mini gun, rocket launcher, and a shoulder mounted mortar capable of sending cluster bomb death to any sniper’s perch.

Luckily, these hulking brutes are usually presented to the player in an inactive state before you lock pick a door or access a certain area, giving you time to prepare for the inevitable conflict ahead. Once they are activated, you’d do best to stay on your toes; The Annihilator Sentry Bot Mk.II will not stop until either you, or it, are defeated.

12 Nukatron Sentinel


An additional robot included as part of the Nuka-World expansion, Nukatron Sentinels are only encountered in the Galactic Zone of Nuka-World. Although they share identical physical traits with their other Sentinel models—save for their bright red paint job—Nukatron Sentinels are extremely deadly. As opposed to the regular arm based laser attack that most Sentinels utilize in combat, the Nukatron Sentinel fires weaponized bursts of Nuka-Cola Cherry and Nuka-Quantum in order down their foes with great efficiency.

Although they ineffectively shuffle around the Galactic Zone bumbling loudly, making them hard to miss and easy to land a sneak attack on, their clumsy nature should not be taken as an indication of their combat effectiveness. They have a massive pool of hit points and are able to absorb a baffling amount of damage and ammunition before finally going down. If at all possible, players are advised to do their best to avoid combat and leave Nukatron Sentinels to their lonely patrol routes.

11 Ancient Behemoth


Super Mutants are pretty common enemy fodder for the Fallout series, making forts and strongholds in the ruined skyscrapers and structures of the wasteland. There are a variety of Super Mutant types from lowly foot soldiers to fearsome Super Mutant Warlords, but none are as feared or as powerful at the Ancient Behemoth. Some of the first experiments conducted by The Institute in Fallout 4, Ancient Behemoths tower over the player at approximately 20 feet tall, wielding a massive club, advancing at an alarming pace, and shaking the ground with their every step.

In addition to dealing massive damage with their bludgeons, Behemoth’s are also capable of stomping the ground, stunning the player, and throwing projectiles should you try to flee from combat. You’ll likely stumble on an Ancient Behemoth laying waste to some of Fallout 4’s other dangerous creatures before setting its sights on you.

10 Quantum Tankbot

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An additional type of robot packaged with the Automatron expansion, Tankbots are hulking powerhouses. Rolling around on treads with a humanoid upper body; Tankbots are best left undisturbed. There are multiple variants, as is typical of Fallout 4 enemies, but none are as resilient as the Quantum Tankbot. Sporting a gatling laser for a right arm and a tesla rifle for its left, they’re able to turn any high level player into a pile of goo within a moments notice.

In addition, they sport an electrified force field that deals damage to any player hoping to charge in and deliver a barrage of melee attacks. Quantum Tankbots are also able to absorb a high level of damage as well, meaning that battles with these lumbering death machines are usually drawn out longer than you’d like. Thankfully, the Quantum Tankbot is a rare occurrence and can usually be shutdown from a nearby computer terminal.

9 Putrid Glowing One


Lower level Feral Ghouls can be tough enough when experienced in a pack, but the experience becomes particularly harrowing when you notice the green iridescent hue of a Glowing One. Glowing Ones are basically over radiated feral ghouls that are nothing but bad news. Not only do they possess the usual speed and ferocity of a normal Feral Ghoul, they deal a lot more damage and tend to be quicker on their feet. Glowing Ones deal radiation damage just from being in their proximity, which is hard to escape as they constantly pursue you once they draw a bead on the player.

As if that wasn’t bad enough, they use a radioactive shockwave attack that can damage you at a distance and heal other nearby Feral Ghouls. Given an opportunity, Glowing Ones will also resurrect slain Feral Ghouls, making their termination in the wasteland a top priority.

8 Dusky Yao Guai


Yao Guais have been a pain in the ass in the Fallout franchise since Fallout 3. Mutated black bears that stalk the wasteland, Yao Guais often appear in the wilds seemingly out of nowhere. No matter your level, they are a constant threat due to their savage speed and attack damage. Players traversing the ruined wastes should always keep their eyes peeled for the infamous Dusky Yao Guai; darker in color and usually with a more scarred hide, these beasts are a real threat, even to higher-level players.

Fast moving damage sponges, Dusky Yao Guais can absorb and put out massive amounts of pain, maiming players with a few swipes. To make matters worse, they are immune to the Animal Friend perk, meaning that they can’t be tamed or avoided. If you see a Dusky Yao Guai cresting the wasteland’s horizon, it’s best to hightail it the other way.

7 Mirelurk Queen


These crustaceous terrors from the deep are luckily only encountered in a few key areas of the game and can prove to be a real pain, especially when part of a group. Larger, more heavily armored, and able to punish players for challenging them in combat, Mirelurk Queens are not an enemy to be trifled with in Fallout 4. In addition to her armored shell and debilitating melee attacks, Mirelurk Queens are also able to spit acid projectiles from a distance.

Mirelurk Queens will also eject a spray of eggs in the heat of combat, spawning a wave of lesser Mirelurk Hatchlings to juggle. Because Mirelurk Queens are usually found in nests abundant with other Mirelurks—including Mirelurk Kings, which lack a shell but can deal massive amounts of damage quickly—the player will usually find themselves surrounded by Mirelurk Killclaws and Glowing Mirelurks before their mighty queen makes herself known.

6 Enraged Fog Crawler


An additional creature class only available in the Far Harbor expansion, Fog Crawlers are basically giant land shrimp from hell. Usually found along the Island’s beaches and coastline, Enraged Fog Crawlers are the toughest of the bunch. Sporting a ridiculous amount of HP, it’ll take more than a few well-placed gauss rifle shots in VATS to down these suckers. Immune to the Wasteland Whisperer perk, an easy way to tell when you’re up against an Enraged Fog Crawler is by making note of the torn pieces of netting and discarded ship parts that will usually accommodate their protective outer-shell.

Enraged Fog Crawlers focus on melee attacks, ripping players limb from limb with giant praying mantis scythe like claws, as well as skewering them with a spear-like nasal appendage. And if you’re planning on bombarding one of these terrors from a distance with a mini-nuke, you’re out of luck; Enraged Fog Crawlers are immune to radiation and poison damage.

5 Deathskull Radscorpion


Another Fallout franchise staple, Radscorpions is a serious pain for any player traveling the wasteland. A heavily armored carapace, cutting pincers, and a long, stinging tail that can poison are all part of this creature's arsenal. When you start hitting the higher levels, you can expect to run into a few Deathskull Radscorpions. They level with the player, meaning that when encountered they’ll always have a tendency to cut your life short if you’re not prepared.

Extremely high damage tolerance and particularly deadly poison in their stingers makes the Deathskull Radscorpion a formidable foe; one strike from their tail is enough to cripple limbs or kill higher level players. If you hear the familiar sound of a Radscorpion surfacing and happen to catch a glimpse of the Deathskull Radscorpion’s noticeably red body, do yourself a favor and hightail it out of there.

4 Gulper Devourer


Next time you’re playing Fallout 4’s DLC expansion Far Harbor, do yourself a favor and keep your eyes on the trees. You may notice a slick looking blob up amongst the branches; take a shot at it or walk too close and it will drop to the ground, resulting in one of your worst nightmares. Gulpers are giant, bipedal salamanders that are fast and deadly. They will charge the player, making use of their melee attacks and fierce speed. Similar to Deathclaws, a player can always try and target their soft underbelly to deal some real damage, but this can prove difficult when trying to survive a giant salamander’s relentless onslaught.

Gulper Devourers are massive compared to the rest of their species; making their physical appearance on par with the damage they’re easily able to deal to the player. Don’t try and make your way around them either, like most of the creatures on this list, they’re immune to the Wasteland Whisperer perk.

3 Synth Eradicator


Synths are the “main” enemies in Fallout 4, a constant synthetic humanoid menace that must be dealt with on the battlefield and, sometimes, in town. Part of the Institute’s android army, Synth Eradicators are some of the most difficult enemies in the game to compete with. You’ll usually find them leading a larger pack of earlier model Synths, taking potshots with some of the highest-level weaponry, safely behind the lines while their expandable brethren keep your attention and ammunition on them.

After the dust has cleared from battling a squad of Synths, expect the Synth Eradicator to come in for the kill. Able to absorb heinous amounts of damage and sporting the Institute’s most advanced weaponry, Synth Eradicators are some of the most dangerous threats to roam the wasteland. Due to their intelligent maneuvers and deadly weapons, your survival chances against a Synth Eradicator—to borrow a line from the Synth themselves—is highly improbable.

2 Mythic Deathclaw


Deathclaws are the reoccurring enemy that the Fallout franchise is known for and Fallout 4 is no exception. Deathclaws are abundant in all corners of the wasteland this time around, and come in a variety of flavors; from your plain, deadly Deathclaw to the more exotic Chameleon Deathclaw, that changes its scales to blend in with its background before releasing a barrage of attacks on the player. There is one that is more deadly than the rest however: the Mythic Deathclaw.

Mythic Deathclaws level with the player, meaning that they will always have that lovely red skull next to their name in combat. These radioactive, reptilian hell beasts are never to be taken lightly, even at higher player levels in the game. When facing a Mythic Deathclaw be sure to come with a fully stocked arsenal and maybe even lob a mini-nuke or two its way.

1 Assaultron Dominator


The Assualtron Dominator is an extremely deadly foe that should always be dealt with using the utmost caution. These cold, calculating, humanoid death machines can be found wandering the wasteland by higher-level players, usually around derelict RobCo buildings. They are fast, efficient, and incredibly tenacious. When they initially spot the player they’ll activate their stealth camouflage, making them incredibly difficult to target in VATS as they unrelentingly charge to get into melee range. If they do get close enough, take heed—the Assaultron Dominator has sword like weapons instead of arms that can cause death in a few swipes.

If you’re able to cripple their legs, they’ll crawl furiously towards you, implementing their devastating head laser if they can get close enough. If you are able to finally put an Assaultron Dominator down, don’t think that you’ve won; Assaultrons self-destruct after being defeated, resulting in instant death for unaware players.

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