The original Vampire: The Masquerade - Bloodlines allowed the player to choose from seven different vampire clans, all of which had their own individual powers, traits, and weaknesses. The same will not be strictly true in the sequel, as the player will be forced to start as the most despised clan of all - the thinbloods - before being given a chance to join a different one.
In the Vampire: The Masquerade tabletop RPG, a vampire is defined by their clan and generation. The player shares the same clan as the person who turned them into a vampire and a vampire's generation is higher than the vampire who turned them, making them weaker. To use an example: an 8th generation Brujah vampire could embrace a mortal and turn them in a vampire and that mortal would become a 9th generation Brujah.
When a vampire of the 13th generation tries to embrace and create a new vampire, then the curse of Caine will be so diluted that the new vampire will not share their clan and will be something known as a Thin-blooded vampire. A thinblood lacks the powers of other vampires, but also lacks their weaknesses, to the point where it is rumored that some thinbloods can eat human food and are unaffected by the sun. The reason why thinbloods are so hated is that it is prophesied that their arrival signals the beginning of the end of the world.
The protagonist of Vampire: The Masquerade - Bloodlines 2 is a thinblood with unique abilities and will be able to choose from the disciplines of Chiropteran (the ability to control and take on aspects of bats), Mentalism (a form of telekinesis), and Nebulation (the ability to control mist), none of which are disciplines used by the other vampire clans.
The official website for Vampire: The Masquerade - Bloodlines 2 lists five empty slots after Thinblood in the Clans section. All players will start out as thinbloods, which suggests that in order to join one of the other clans, the player will need to commit the act of Diablerie, which involves slaying another vampire by drinking both their blood and their soul. Diablerie is considered to be one of the worst crimes a vampire can commit, so it would be interesting to see how (or if) it's worked into the story of Vampire: The Masquerade - Bloodlines 2.
Vampire: The Masquerade - Bloodlines 2 will be available for PC, PlayStation 4, and Xbox One in Q1, 2020.